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imc-3g3, a fully human igg1 monoclonal antibody against pdgfr-α  (ImClone Inc)

 
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    ImClone Inc imc-3g3, a fully human igg1 monoclonal antibody against pdgfr-α
    Imc 3g3, A Fully Human Igg1 Monoclonal Antibody Against Pdgfr α, supplied by ImClone Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/imc-3g3+antibody/imc+a12+antibody/us10676527-312-25-36
    Average 90 stars, based on 1 article reviews
    imc-3g3, a fully human igg1 monoclonal antibody against pdgfr-α - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Blocking Assay:

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Angiogenesis inhibitors for the treatment of ovarian cancer
    Article Snippet: A total of 110 enrolled patients is aimed for; 25 patients had been enrolled at 6 sites as of January 2010 Interventions Randomisation to either arm A or arm B, continuing until disease progression or other withdrawal criteria: arm A: doxorubicin (40 mg/m2) every 4 weeks + IMC-3G3 (20 mg/kg) every 2 weeks arm B: doxorubicin (40 mg/m2) every 4 weeks Patients in arm B may receive IMC-3G3 monotherapy upon disease progression [IMC-3G3 is an inhibitor of PDGF-R-alpha, another tyrosine-kinase enzyme involved in angiogenesis, and which is often associated with VEGF-R.] Outcomes Primary: • PFS Secondary: • OS • objective response rate • median duration of response • adverse events • IMC-3G3 antibody and pharmacokinetic assessments Starting date June 2009 Contact information Email: ClinicalTrials@ImClone.com 41Angiogenesis inhibitors for the treatment of ovarian cancer (Review) Copyright © 2011 The Cochrane Collaboration.

    Article Title: Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma
    Article Snippet: IMC-3G3 is a fully human anti-PDGFRα monoclonal antibody stocked as a 5 mg/mL concentration (ImClone Systems, New York, NY) [ 9 ].

    Article Title: The α-Receptor for Platelet-Derived Growth Factor Confers Bone-Metastatic Potential to Prostate Cancer Cells by Ligand- and Dimerization-Independent Mechanisms
    Article Snippet: We thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα-expressing vector, and Dr. Nick Loizos (ImClone Systems, Inc., New York, NY) for providing the IMC-3G3 antibody.

    Article Title: THE ALPHA RECEPTOR FOR PLATELET DERIVED GROWTH FACTOR CONFERS BONE-METASTATIC POTENTIAL TO PROSTATE CANCER CELLS BY LIGAND- AND DIMERIZATION-INDEPENDENT MECHANISMS
    Article Snippet: The authors wish to thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Mr. Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα expressing vector, Dr. Nick Loizos (ImClone Systems Inc., NY) for providing the IMC-3G3 antibody.

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus–Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia
    Article Snippet: Monoclonal IMC-3G3 antibody was kindly provided by Dr. Nick Loizos, ImClone Systems Corporation (Bridgewater, NJ).

    Article Title: Monoclonal Antibodies for the Treatment of Cancer
    Article Snippet: IMC-3G3 (ImClone Systems) is an IgG1 that binds to PDGFRα with high affinity, blocking its activation [ 65 ].

    Activation Assay:

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Angiogenesis inhibitors for the treatment of ovarian cancer
    Article Snippet: A total of 110 enrolled patients is aimed for; 25 patients had been enrolled at 6 sites as of January 2010 Interventions Randomisation to either arm A or arm B, continuing until disease progression or other withdrawal criteria: arm A: doxorubicin (40 mg/m2) every 4 weeks + IMC-3G3 (20 mg/kg) every 2 weeks arm B: doxorubicin (40 mg/m2) every 4 weeks Patients in arm B may receive IMC-3G3 monotherapy upon disease progression [IMC-3G3 is an inhibitor of PDGF-R-alpha, another tyrosine-kinase enzyme involved in angiogenesis, and which is often associated with VEGF-R.] Outcomes Primary: • PFS Secondary: • OS • objective response rate • median duration of response • adverse events • IMC-3G3 antibody and pharmacokinetic assessments Starting date June 2009 Contact information Email: ClinicalTrials@ImClone.com 41Angiogenesis inhibitors for the treatment of ovarian cancer (Review) Copyright © 2011 The Cochrane Collaboration.

    Article Title: Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma
    Article Snippet: IMC-3G3 is a fully human anti-PDGFRα monoclonal antibody stocked as a 5 mg/mL concentration (ImClone Systems, New York, NY) [ 9 ].

    Article Title: The α-Receptor for Platelet-Derived Growth Factor Confers Bone-Metastatic Potential to Prostate Cancer Cells by Ligand- and Dimerization-Independent Mechanisms
    Article Snippet: We thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα-expressing vector, and Dr. Nick Loizos (ImClone Systems, Inc., New York, NY) for providing the IMC-3G3 antibody.

    Article Title: THE ALPHA RECEPTOR FOR PLATELET DERIVED GROWTH FACTOR CONFERS BONE-METASTATIC POTENTIAL TO PROSTATE CANCER CELLS BY LIGAND- AND DIMERIZATION-INDEPENDENT MECHANISMS
    Article Snippet: The authors wish to thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Mr. Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα expressing vector, Dr. Nick Loizos (ImClone Systems Inc., NY) for providing the IMC-3G3 antibody.

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus–Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia
    Article Snippet: Monoclonal IMC-3G3 antibody was kindly provided by Dr. Nick Loizos, ImClone Systems Corporation (Bridgewater, NJ).

    Article Title: Monoclonal Antibodies for the Treatment of Cancer
    Article Snippet: IMC-3G3 (ImClone Systems) is an IgG1 that binds to PDGFRα with high affinity, blocking its activation [ 65 ].

    Expressing:

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Angiogenesis inhibitors for the treatment of ovarian cancer
    Article Snippet: A total of 110 enrolled patients is aimed for; 25 patients had been enrolled at 6 sites as of January 2010 Interventions Randomisation to either arm A or arm B, continuing until disease progression or other withdrawal criteria: arm A: doxorubicin (40 mg/m2) every 4 weeks + IMC-3G3 (20 mg/kg) every 2 weeks arm B: doxorubicin (40 mg/m2) every 4 weeks Patients in arm B may receive IMC-3G3 monotherapy upon disease progression [IMC-3G3 is an inhibitor of PDGF-R-alpha, another tyrosine-kinase enzyme involved in angiogenesis, and which is often associated with VEGF-R.] Outcomes Primary: • PFS Secondary: • OS • objective response rate • median duration of response • adverse events • IMC-3G3 antibody and pharmacokinetic assessments Starting date June 2009 Contact information Email: ClinicalTrials@ImClone.com 41Angiogenesis inhibitors for the treatment of ovarian cancer (Review) Copyright © 2011 The Cochrane Collaboration.

    Article Title: Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma
    Article Snippet: IMC-3G3 is a fully human anti-PDGFRα monoclonal antibody stocked as a 5 mg/mL concentration (ImClone Systems, New York, NY) [ 9 ].

    Article Title: The α-Receptor for Platelet-Derived Growth Factor Confers Bone-Metastatic Potential to Prostate Cancer Cells by Ligand- and Dimerization-Independent Mechanisms
    Article Snippet: We thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα-expressing vector, and Dr. Nick Loizos (ImClone Systems, Inc., New York, NY) for providing the IMC-3G3 antibody.

    Article Title: THE ALPHA RECEPTOR FOR PLATELET DERIVED GROWTH FACTOR CONFERS BONE-METASTATIC POTENTIAL TO PROSTATE CANCER CELLS BY LIGAND- AND DIMERIZATION-INDEPENDENT MECHANISMS
    Article Snippet: The authors wish to thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Mr. Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα expressing vector, Dr. Nick Loizos (ImClone Systems Inc., NY) for providing the IMC-3G3 antibody.

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus–Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia
    Article Snippet: Monoclonal IMC-3G3 antibody was kindly provided by Dr. Nick Loizos, ImClone Systems Corporation (Bridgewater, NJ).

    Article Title: Monoclonal Antibodies for the Treatment of Cancer
    Article Snippet: IMC-3G3 (ImClone Systems) is an IgG1 that binds to PDGFRα with high affinity, blocking its activation [ 65 ].

    Plasmid Preparation:

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Angiogenesis inhibitors for the treatment of ovarian cancer
    Article Snippet: A total of 110 enrolled patients is aimed for; 25 patients had been enrolled at 6 sites as of January 2010 Interventions Randomisation to either arm A or arm B, continuing until disease progression or other withdrawal criteria: arm A: doxorubicin (40 mg/m2) every 4 weeks + IMC-3G3 (20 mg/kg) every 2 weeks arm B: doxorubicin (40 mg/m2) every 4 weeks Patients in arm B may receive IMC-3G3 monotherapy upon disease progression [IMC-3G3 is an inhibitor of PDGF-R-alpha, another tyrosine-kinase enzyme involved in angiogenesis, and which is often associated with VEGF-R.] Outcomes Primary: • PFS Secondary: • OS • objective response rate • median duration of response • adverse events • IMC-3G3 antibody and pharmacokinetic assessments Starting date June 2009 Contact information Email: ClinicalTrials@ImClone.com 41Angiogenesis inhibitors for the treatment of ovarian cancer (Review) Copyright © 2011 The Cochrane Collaboration.

    Article Title: Platelet-derived growth factor receptor alpha (PDGFRα) targeting and relevant biomarkers in ovarian carcinoma
    Article Snippet: IMC-3G3 is a fully human anti-PDGFRα monoclonal antibody stocked as a 5 mg/mL concentration (ImClone Systems, New York, NY) [ 9 ].

    Article Title: The α-Receptor for Platelet-Derived Growth Factor Confers Bone-Metastatic Potential to Prostate Cancer Cells by Ligand- and Dimerization-Independent Mechanisms
    Article Snippet: We thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα-expressing vector, and Dr. Nick Loizos (ImClone Systems, Inc., New York, NY) for providing the IMC-3G3 antibody.

    Article Title: THE ALPHA RECEPTOR FOR PLATELET DERIVED GROWTH FACTOR CONFERS BONE-METASTATIC POTENTIAL TO PROSTATE CANCER CELLS BY LIGAND- AND DIMERIZATION-INDEPENDENT MECHANISMS
    Article Snippet: The authors wish to thank Dr. Olimpia Meucci (Drexel College of Medicine) for helpful discussion, Dr. Gregg Johannes and Mr. Jeff Thomas (Department of Pathology, Drexel College of Medicine) for help with the PDGFRα expressing vector, Dr. Nick Loizos (ImClone Systems Inc., NY) for providing the IMC-3G3 antibody.

    Article Title: Methods and compositions for modulation of blood-neural barrier
    Article Snippet: Also, numerous anti-PDGFR-α antibodies are available, including anti-human PDGFR-α polyclonal and monoclonal antibodies that can be obtained commercially from R&D Systems, Inc., Minneapolis, Minn., and IMC-3G3, a fully human IgG1 monoclonal antibody against PDGFR-α, available from Imclone, Inc.

    Article Title: Ligand-Independent Activation of Platelet-Derived Growth Factor Receptor β during Human Immunodeficiency Virus–Transactivator of Transcription and Cocaine-Mediated Smooth Muscle Hyperplasia
    Article Snippet: Monoclonal IMC-3G3 antibody was kindly provided by Dr. Nick Loizos, ImClone Systems Corporation (Bridgewater, NJ).

    Article Title: Monoclonal Antibodies for the Treatment of Cancer
    Article Snippet: IMC-3G3 (ImClone Systems) is an IgG1 that binds to PDGFRα with high affinity, blocking its activation [ 65 ].



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    Lipid-based nanomedicines for the development of drug-resistant cancer treatments, selected from phase I, II, and III clinical trials

    Journal: Cancer Drug Resistance

    Article Title: Recent advanced lipid-based nanomedicines for overcoming cancer resistance

    doi: 10.20517/cdr.2024.19

    Figure Lengend Snippet: Lipid-based nanomedicines for the development of drug-resistant cancer treatments, selected from phase I, II, and III clinical trials

    Article Snippet: NCT00913835 (phase II, completed, 2019) , Eli Lilly and Company , 1. Olaratumab + PLD 2. PLD or olaratumab monotherapy , Randomized phase 2 trial investigating liposomal doxorubicin with or without anti-PDGFRα monoclonal antibody IMC-3G3 in patients with platinum-refractory or platinum-resistant advanced ovarian cancer.

    Techniques: Injection, Activity Assay, Activation Assay, Formulation, Mutagenesis